![]() Outside of its effects on mitochondria, CCCP may also disrupt lysosomal degradation during autophagy. It is routinely used as an experimental uncoupling agent in cell and molecular biology, particularly in the study of mitophagy, where it was integral in discovering the role of the Parkinson's disease-associated ubiquitin ligase Parkin. The chemical acts essentially as an ionophore and reduces the ability of ATP synthase to function optimally. ![]() ![]() CCCP causes an uncoupling of the proton gradient that is established during the normal activity of electron carriers in the electron transport chain. elegans models, suggesting a degree of hormesis. In general, CCCP causes the gradual destruction of living cells and death of the organism, although mild doses inducing partial decoupling have been shown to increase median and maximum lifespan in C. It is a nitrile, hydrazone and protonophore. Carbonyl cyanide m-chlorophenyl hydrazone ( CCCP also known as malononitrile) is a chemical inhibitor of oxidative phosphorylation.
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